Our paper on using CRISPR-Cas tools in Streptomyces to activate silent natural products is out!7/15/2022
Bacteria can synthesize a staggering repertoire of complex chemical molecules with valuable properties. While a large repertoire of uncharacterized natural products exists, a critical barrier to their discovery is that bacteria do not synthesize these chemicals when grown in the laboratory. In our latest publication in NAR, we created new synthetic transcription factors based upon CRISPR-Cas systems that can be used to reprogram cells into natural product synthesizing phenotypes.
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